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Synlett 2001; 2001(9): 1421-1422
DOI: 10.1055/s-2001-16807
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Selective Oxidation of Propargylic Alcohols into α,β-Acetylenic Aldehydes with a TiCl4/Et3N System

Zhenfu Han* , Hiroshi Shinokubo, Koichiro Oshima
  • *Department of Material Chemistry, Graudate School of Engineering, Kyoto University, Yoshida, Sakyo-ku, Kyoto 606-8501, Japan; Fax: + 81-75-753-4863 E-mail: oshima@fm1.kuic.kyoto-u.ac.jp
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Publication Date:
28 August 2001 (online)

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A TiCl4/Et3N combination proved to be effective for the selective oxidation of propargylic alcohols into α,β-acetylenic aldehydes in good yields. Treatment of 2-hexyne-1,6-diol with TiCl4/Et3N provided 6-hydroxy-2-hexynal in good yield.

oxidation - propargylic alcohol - α,β-acetylenic aldehyde - TiCl4/Et3N

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