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Synlett 2001; 2001(9): 1485-1487
DOI: 10.1055/s-2001-16798
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Aminolysis of Esters or Lactones Promoted by NaHMDS - A General and Efficient Method for the Preparation of N-Aryl Amides

Jianji Wang* , Miguel Rosingana, Robert P. Discordia, Nachimuthu Soundararajan, Richard Polniaszek
  • *Process Research & Development Department, Pharmaceutical Research Institute, Bristol-Myers Squibb Co., New Brunswick, NJ 08903, USA; Fax (732) 519-3240; E-mail: jianji.wang@bms.com
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Publication Date:
28 August 2001 (online)

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An efficient method for the preparation of N-aryl amides from anilines, esters or lactones promoted by NaHMDS is described. Advantages of this new method include high yields and mild reaction conditions which tolerate functional groups such as ketones and halides.

aminolysis - amides - anilines - esters - halides

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