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Synlett 2001; 2001(9): 1375-1378
DOI: 10.1055/s-2001-16791
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Novel Biphenol Phosphoramidite Ligands for the Enantioselective Copper-Catalyzed Conjugate Addition of Dialkyl zincs

Alexandre Alexakis* , Stéphane Rosset, Janik Allamand, Sébastien March, Frédéric Guillen, Cyril Benhaim
  • *Department of Organic Chemistry, University of Geneva, 30 quai Ernest Ansermet, Genève 4, Switzerland CH-1211; Fax (41 22) 328 73 96; E-mail: alexandre.alexakis@chiorg.unige.ch
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Publication Date:
28 August 2001 (online)

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Phosphoramidite ligands, based on a chiral amine and atropoisomerically flexible biphenols, induce high enantioselectivities (ee's up to 98%) in the copper-catalyzed conjugate addition of dialkyl zinc reagents to a variety of Michael acceptors.

asymmetric catalysis - copper - zinc - Michael additions - phosphorus - atropoisomerism

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