Subscribe to RSS
Synthesis of Structurally Diversified α-Substituted β-Amino Acids and Derivatives via Conjugate Radical Additions and Heck Reactions
28 August 2001 (online)
An efficient short-step synthesis of α-substituted β-amino, β-hydrazino, β-N-hydroxy esters and β-urethane N-carboxyanhydrides is reported. Structural diversity was easily incorporated in good yields at the α position of the carboxylic group via conjugate radical additions and Heck reactions performed on the conjugated double bond of synthons 3, 8 and 9.
α-substituted β-amino acids - radical addition - Heck reaction - β-UNCAs