Synlett 2001; 2001(9): 1423-1427
DOI: 10.1055/s-2001-16780
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Synthesis of SB-214857 using Copper Catalysed Amination of Arylbromides with l-Aspartic Acid

Jean-Baptiste Clement* , Jerome F. Hayes, Helen M. Sheldrake, Peter W. Sheldrake, Andrew S. Wells
  • *GlaxoSmithKline Pharmaceuticals, Old Powder Mills, Nr Leigh, Tonbridge, Kent, TN11 9AN, UK; E-mail: hayesj00@sbphrd.com
Further Information

Publication History

Publication Date:
28 August 2001 (online)

An efficient synthesis of a 1,4-benzodiazepine was accomplished using copper catalysed amination of an arylbromide with the soluble bis-tetrabutylammonium salt of l-aspartic acid as a key step.