One-Pot Synthesis of Indoles from Ketones and Hydrazines under Mild Reaction Conditions

Abstract

A facile one-pot method is presented for the synthesis of indoles via condensation of ketone with hydrazine followed by acylation and rearrangement. This convenient synthetic method provides an easy and simple access to indoles.

Key words

N-trifluoroacetyl enehydrazine - ketone - indole - indoline - one-pot synthesis

References and Notes

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9

The acylation using 1 equiv of TFAA was not completed.