Microwave-Assisted Solid-Support Synthesis of Pyrazolino/Iminopyrimidino/Thioxopyrimidino Imidazolines

Mazzahir Kidwai; Pooja Sapra; Kumar Ranjan Bhushan; Preeti Misra

doi:10.1055/s-2001-16088

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Synthesis 2001(10): 1509-1512
DOI: 10.1055/s-2001-16088

PAPER

Microwave-Assisted Solid-Support Synthesis of Pyrazolino/Iminopyrimidino/Thioxopyrimidino Imidazolines

Mazzahir Kidwai*, Pooja Sapra, Kumar Ranjan Bhushan, Preeti Misra
Department of Chemistry, University of Delhi, Delhi-110007, India
Fax: +91(11)7256235; e-Mail: mkidwai@mantraonline.com;

Further Information

Publication History

Received 9 January 2001
Publication Date:
29 September 2004 (online)

Abstract
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Abstract

An expeditious solvent-free synthesis of pyrazolino/iminopyrimidino/thioxopyrimidino imidazoline derivatives from readily accessible oxazolones on solid support using microwaves is described. The reaction time has been brought down from hours to minutes with improved yield as compared to conventional heating.

Key words

microwave irradiation - solid-support synthesis - heterocycles

References

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Aluminium Oxide Basic, Brockmann I (Aldrich Chem. Co., Cat. No. 19, 944-3, ~150 mesh, 58 Å, Surface area 155 m²/g)was used. Alumium Oxide Neutral, Brockmann I (Aldrich Chem. Co., Cat. No. 19, 997-4, ~150 mesh, 58 Å, Surface area 155 m²/g)was used.