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Synlett 2001; 2001(7): 1125-1126
DOI: 10.1055/s-2001-15148
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Elaboration of New Monoterpenoid Indole Alkaloids Containing a Dihydrofuran Unit

Ahcène Boumendjel* , Jean-Marc Nuzillard, Georges Massiot
  • *Département de Pharmacochimie Moléculaire UMR-CNRS 5063, UFR de Pharmacie de Grenoble 38706 La Tronche, France; Fax (33) 4 76 63 71 65; E-mail: Ahcene.Boumendjel@ujf-grenoble.fr
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Publication Date:
31 December 2001 (online)

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Reaction of methyl fluorodiethylphosphonoacetate with N4-Boc-3-formylmethyl-tetrahydro-β-carboline gave the corresponding methyl fluoroacrylate. The latter was found to be a useful intermediate in the synthesis of new heteroyohimbine indole alkaloids possessing a dihydrofuran unit.

unsaturated fluorolactam - fluoroacrylate - cyclisation - heteroyohimbine alkaloids

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