Synlett 2001; 2001(Special Issue): 1050-1054
DOI: 10.1055/s-2001-14659
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Synthesis and Structural Characterization of a Highly Effective Chiral Dipyridylphosphine Ligand and Its Application in the Ru-Catalyzed Asymmetric Hydrogenation of β-Ketoesters

Jing Wu* , Hua Chen, Zhong-Yuan Zhou, Chi Hung Yeung, Albert S. C. Chan
  • *Open Laboratory of Chirotechnology and Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong; Fax + 852 23 64 99 32; E-mail: bcachan@polyu.edu.hk
Further Information

Publication History

Publication Date:
31 December 2001 (online)

A new chiral dipyridylphosphine ligand Tol-P-Phos has been synthesized and the structure of the complex of (R)-Tol-P-Phos oxide with (-)-dibenzoyl-l-tartaric acid [(-)-DBT] was determined by single crystal X-ray diffraction. The ruthenium complex of Tol-P-Phos, Ru(R-Tol-P-Phos)(C6H6)Cl2, has been found to be a highly active and enantioselective catalyst in the asymmetric hydrogenation of β-ketoesters (up to 98.2% e.e.). The catalyst is also found to be air-stable even in solution.

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