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Synlett 2001; 2001(Special Issue): 0931-0936
DOI: 10.1055/s-2001-14624
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Recognition of β-Ketoalcohol-derived Haptens by Tailor-made Antibodies

Alain Krief* , Jean-Jacques Letesson, Dominique Swinnen, Denis Billen
  • *Laboratoire de Chimie Organique de Synthèse, Département de Chimie, Facultés Universitaires Notre-Dame de la Paix, 61 rue de Bruxelles, B-5000 Namur, Belgium; Fax + 32 81 72 45 36; E-mail: alain.krief@fundp.ac.be
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Publication Date:
31 December 2001 (online)

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Antibodies steamed from mice immunized towards three different conjugates do not recognize the β-ketoalcohol for which they have been elaborated. They however recognize the haptens, which bear the side chain linking them to the carrier proteins. We have synthesized and tested for recognition a series of compounds related to those haptens, especially stereoisomers and compounds bearing part of their structures. Results and hypotheses are presented below.

antibodies - β-ketoalcohols - lipases - recognition - sulfur ylides

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