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Dtsch Med Wochenschr 2001; 126(21): 625-627
DOI: 10.1055/s-2001-14417
DOI: 10.1055/s-2001-14417
Der Arzneistoff
© Georg Thieme Verlag Stuttgart · New YorkAmiodaron
AmiodaroneFurther Information
Publication History
Publication Date:
31 December 2001 (online)

Amiodaron wurde ursprünglich in den 60er Jahren als Pharmakon zur Therapie der Angina pectoris eingeführt. Erst später wurden die antiarrhythmischen Eigenschaften von Amiodaron erkannt [1-3].
Literatur
- 1
Charlier R.
Récherches
dans la séries des benzfurannes. VII. Etude pharmacologique
préliminaire du butyl-2(diiodo-3’,5’-B-N-diethylaminoethoxy-4’ benzoyl)-3
benzfuranne.
Arch Int Pharmacodyn.
1962;
139
255-262
MissingFormLabel
- 2
Singh B N.
Amiodarone:
historical development and pharmacologic profile.
Am Heart
J.
1983;
106
788-797
MissingFormLabel
- 3
Vastesaeger M.
Etude
clinique d’une nouvelle médication antiangoreuse.
Acta Cardiol
(Brux).
1964;
22
483
MissingFormLabel
- 4
Lai L P, Su M J, Tseng Y Z, Lien W P.
Sensitivity of
the slow component of the delayed rectifier potassium current (IKs)
to potassium channel blockers: Implications for clinical reverse
use-dependent effects.
J Biomed Sci.
1999;
6
251-259
MissingFormLabel
- 5
Sanguinetti M C, Jurkiewicz N K.
Two components
of cardiac delayed rectifier K+ current. Differential sensitivity
to block by class III antiarrhythmic agents.
J Gen Physiol.
1990;
96
195-215
MissingFormLabel
- 6
Julian D G, Camm A J, Frangin G, Janse M J, Munoz A, Schwartz P J, Simon P.
Investigators:
EMIAT. Randomized trial of effect of amiodarone on mortality in
patients with left-ventricular dysfunction after recent myocardial
infarction: EMIAT.
Lancet.
1997;
349
667-674
MissingFormLabel
- 7
Amiodarone Trials
Meta-analysis Investigators .
The effect of prophylactic
amiodarone on mortality after acute myocardial infarction and in
congestive heart failure: meta-analysis of individual patient data
on 6500 patients from randomized trials.
Lancet.
1997;
350
1417-1424
MissingFormLabel
- 8
Hohnloser S H, Klingenheben T, Singh B N.
Amiodarone-associated
proarrhythmic effects. A review with special reference to torsade
de pointes tachycardia.
Ann Intern Med.
1994;
121
529-535
MissingFormLabel
- 9
Cairns J A, Connolly S J, Roberts R S, Gent M, Investigators T C.
Randomized
trial of outcome after myocardial infarction in patients with frequent
or repetitive ventricular premature depolarizations: CAMIAT.
Lancet.
1997;
349
675-682
MissingFormLabel
- 10
Yin Y L, Perret G Y, Nicolas P, Vassy R, Uzzan B, Tod M.
In
vivo effects of amiodarone on cardiac beta-adrenoceptor density and
heart rate require thyroid hormones.
J Cardiovasc Pharmacol.
1992;
19
541-545
MissingFormLabel
- 11
Latham K R, Sellitti D F, Goldstein R E.
Interaction
of amiodarone and desethylamiodarone with solubilized nuclear thyroid
hormone receptors.
J Am Coll Cardiol.
1987;
9
872-876
MissingFormLabel
- 12
Drvota V, Blange I, Haggblad J, Sylven C.
Desethylamiodarone
prolongation of cardiac repolarization is dependent on gene expression:
a novel antiarrhythmic mechanism.
J Cardiovasc Pharmacol.
1998;
32
654-661
MissingFormLabel
- 13
van Beeren H C, Bakker O, Wiersinga W M.
Structure-function
relationship of the inhibition of the 3,5,3’-triiodothyronine binding
to the alpha1- and beta1-thyroid hormone receptor by amiodarone
analogs.
Endocrinology.
1996;
137
2807-2814
MissingFormLabel
- 14
Aanderaud S, Sundsfjord J, Aarbokke J.
Amiodarone
inhibits the conversion of thyroxin to triiodothyronine inisolated rat
heaptocytes.
Endocrinology.
1984;
115
1605-1608
MissingFormLabel
- 15
Krenning E P, Docter R, Bernard B, Visser T, Hennemann G.
Decreased
transport of thyroxine (T4), 3,3’,5-triiodothyronine (T3)
and 3,3’,5’-triiodothyronine (rT3) into rat hepatocytes
in primary culture due to a decrease of cellular ATP content and
various drugs.
FEBS Lett.
1982;
140
229-233
MissingFormLabel
- 16
Connolly S J.
Meta-analysis
of antiarrhythmic drug trials.
Am J Cardiol.
1999;
84
90R-93R
MissingFormLabel
- 17
Connolly S J.
Evidence-based
analysis of amiodarone efficacy and safety.
Circulation.
1999;
100
2025-2034
MissingFormLabel
- 18
Herbette L G, Trumbore M, Chester D W, Katz A M.
Possible molecular
basis for the pharmacokinetics and pharmacodynamics of three membrane-active
drugs: propranolol, nimodipine and amiodarone.
J Mol Cell
Cardiol.
1988;
20
373-378
MissingFormLabel
- 19
Hein L, Lüllmann-Rauch R, Mohr K.
Human accumulation potential
of xenobiotics: potential of catamphiphilic drugs to promote their
accumulation via inducing lipidosis or mucopolysaccharidosis.
Xenobiotica.
1990;
20
1259-1267
MissingFormLabel
- 20
Holt D W, Tucker G T, Jackson P R, Storey G CA.
Amiodarone
pharmacokinetics.
Am Heart J.
1983;
106
840-847
MissingFormLabel
- 21
Adams P C, Holt D W, Storey G CA, Morley A R, Callaghan J, Path M RC, Campbell R WF.
Amiodarone
and its desethyl metabolite: tissue distribution and morphologic
changes during long-term therapy.
Ther Prev Pharmacol.
1985;
72
1064-1075
MissingFormLabel
- 22
Pollak P T, Bouillon T, Shafer S L.
Population
pharmacokinetics of long-term oral amiodarone therapy.
Clin
Pharmacol Ther.
2000;
67
642-652
MissingFormLabel
- 23
Mason J W.
Amiodarone.
N
Engl J Med.
1987;
316
455-466
MissingFormLabel
- 24
Francois J.
Cornea
verticillata.
Bull Soc Belge Ophthalmol.
1968;
150
656-670
MissingFormLabel
- 25
D’Amico D J, Kenyon K R, Ruskin J N.
Amiodarone
keratopathy: drug-induced lipid storage disease.
Arch Ophthalmol.
1981;
99
257-261
MissingFormLabel
- 26
Pollak P T.
Clinical
organ toxicity of antiarrhythmic compounds: ocular and pulmonary
manifestations.
Am J Cardiol.
1999;
84
37R-45R
MissingFormLabel
- 27
Vorperian V R, Havighurst T C, Miller S, January C T.
Adverse effects
of low dose amiodarone: a meta-analysis.
J Am Coll Cardiol.
1997;
30
791-798
MissingFormLabel
- 28
Loh K C.
Amiodarone-induced
thyroid disorders: A clinical review.
Postgrad Med J.
2000;
76
133-140
MissingFormLabel
- 29
Hennersdorf M G, Strauer B E.
Herzrhythmusstörungen
bei Hyperthyreose.
Dtsch Med Wschr.
2000;
125
637-641
MissingFormLabel
Korrespondenz
PD Dr. med. Lutz Hein
Institut für Pharmakologie Universität
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