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Dtsch Med Wochenschr 2001; 126(20): 597-604
DOI: 10.1055/s-2001-14106
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© Georg Thieme Verlag Stuttgart · New York

Klinische Wirkungen und Pharmakodynamik der Insulinanaloga Lispro, Aspart und Glargin

Clinical efficacy and pharmacodynamics of the insulin analogs lispro, aspart and glarginL. Heinemann, T. Heise
  • Profil Institut für Stoffwechselforschung GmbH, Neuss
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Publication Date:
31 December 2001 (online)

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Subkutane Injektion der bisher üblichen Insulinpräparationen ermöglicht keine optimale Imitation des endogenen Insulinsekretionsmusters, da subkutan injiziertes Normalinsulin einen zu langsamen Wirkbeginn und eine zu lange Wirkdauer (bis zu 12 h bei Verwendung hoher Dosen) aufweist [Abb. 1] [30]. Das als Verzögerungsinsulin verwendete NPH-Insulin weist nicht den gewünschten niedrigen und konstanten metabolischen Effekt über die Zeit auf, sondern eine ausgeprägte maximale Wirkung nach ca. 6 h, mit einem konstanten Absinken der Wirkung in der Zeit danach [Abb. 1] [36]. Unter anderem deshalb gelingt es vielen Diabetes-Patienten nicht, eine gute Stoffwechselkontrolle zu etablieren [5] [7] [9] .

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Korrespondenz

PD Dr. Lutz Heinemann

Profil Institut für Stoffwechselforschung GmbH

Stresemannallee 6

41460 Neuss

Phone: 02131/155402

Fax: 02131/155 409

Email: Lutz.Heinemann@profil-research.de

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