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Synthesis 2001(6): 0871-0876
DOI: 10.1055/s-2001-13409
PAPER
© Georg Thieme Verlag Stuttgart · New York

Pyridazines Part XXIII: [1] Efficient Arylation at Position 5 of the 6-Phenyl-(2H)-pyridazin-3-one System Using a Suzuki Cross-Coupling Reaction

Alberto Coelho, Eddy Sotelo, Isabel Estévez, Enrique Raviña*
Departamento de Química Orgánica, Laboratorio de Química Farmacéutica, Facultad de Farmacia, Universidad de Santiago de Compostela, 15706 Santiago de Compostela, Spain.
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Publication History

Received 29 December 2000
Publication Date:
24 September 2004 (online)

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Abstract

A highly efficient procedure for introducing aryl or heteroaryl rings at position 5 of the 6-phenyl-(2H)-pyridazin-3-one system using a Suzuki cross-coupling reaction has been developed in the search for new platelet aggregation inhibitors.

Key words

arylations - palladium - catalysis - pyridazin-3-ones

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