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Synlett 2001; 2001(5): 0637-0639
DOI: 10.1055/s-2001-13386
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Lewis Acid-Promoted Transesterification of N-Acyl Oxazolidinones under Mild Conditions

Akihiro Orita* , Yoshifumi Nagano, Junichi Hirano, Junzo Otera
  • *Department of Applied Chemistry, Okayama University of Science, Ridai-cho, Okayama 700-0005, Japan; Fax + 81 86 256 4292; E-mail: otera@high.ous.ac.jp
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Publication History

Publication Date:
31 December 2001 (online)

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N-Acyl oxazolidinones are smoothly converted to the corresponding esters by Lewis acid-promoted transesterification. Mild reaction conditions suppress epimerization or racemization of chiral substrates and allow acid-sensitive groups to survive.

oxazolidinone - transesterification - Lewis acid