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Synlett 2001; 2001(5): 0676-0678
DOI: 10.1055/s-2001-13376
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A Microwave-Enhanced, Solventless Mannich Condensation on CuI-Doped Alumina

G. W. Kabalka* , L. Wang, R. M. Pagni
  • *Departments of Chemistry and Radiology, The University of Tennessee, Knoxville, Tennessee 37996-1600 U.S.A.; Fax (865)974-2997; Phone (865)974-3260; E-mail: kabalka@utk.edu
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Publication Date:
31 December 2001 (online)

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Terminal alkynes react with secondary amines and para-formaldehyde to afford Mannich adducts in the presence of cuprous iodide on alumina under microwave irradiation and solvent free conditions.

Mannich condensation - microwave irradiation - alumina - aminoalkynes