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Synlett 2001; 2001(5): 0646-0648
DOI: 10.1055/s-2001-13355
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A Carbonyl Ylide Approach to Substituted Furans

Tim Johnson* , David R. Cheshire, Michael J. Stocks, Vicky T. Thurston
  • *Department of Medicinal Chemistry, AstraZeneca R&D Charnwood, Bakewell Road, Loughborough, LE11 5RH, UK; Fax + 44 1509 64 55 71; E-mail: tim.johnson1@astrazeneca.com
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Publication History

Publication Date:
31 December 2001 (online)

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The diazosulphone 1 undergoes intermolecular reaction with aldehydes to form carbonyl ylides 2. This reactive intermediate can then be trapped, in an inter- or intramolecular reaction, by alkynes or alkenes to yield substituted furans or tetrahydrofurans respectively.

diazo compounds - carbonyl ylide - ring closure - furans

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