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Synthesis 2001; 2001(4): 0595-0600
DOI: 10.1055/s-2001-12365
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Reactivity of a 6-Chloroimidazo[1,2-b]pyridazine Derivative Towards Suzuki Cross-Coupling Reaction

Cécile Enguehard* , Maud Hervet, Hassan Allouchi, Jean-Claude Debouzy, Jean-Michel Leger, Alain Gueiffier
  • *Laboratoire de Chimie Thérapeutique, Faculté de Pharmacie, 31 Avenue Monge, 37200 Tours, France; Fax + (33)02 47 36 72 88; E-mail: gueiffier@univ-tours.fr.
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Publication Date:
31 December 2001 (online)

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The influence of base, reaction time and boronic acid in the Suzuki cross-coupling reaction on 6-chloro-2-(4-fluorophenyl)imidazo[1,2-b]pyridazine is reported. The crystal data for the thien-2-yl compound 7 is also described.

imidazo[1,2-b]pyridazine - cross-coupling - palladium - arylations - alkylation