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Synthesis 2001; 2001(4): 0550-0552
DOI: 10.1055/s-2001-12350
short paper
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Imidazole and Trifluoroethanol as Efficient and Mild Reagents for Destruction of Excess Di-tert-butyl Dicarbonate [(BOC)2O]

Yochai Basel* , Alfred Hassner
  • *Department of Chemistry, Bar-Ilan University, Ramat Gan 52900, Israel
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Publication Date:
31 December 2001 (online)

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Mild and efficient procedures employing inexpensive reagents (imidazole or trifluoroethanol) for the removal of excess (BOC)2O, usually used during NH or OH protection at room temperature, are described. The use of polymer-based DMAP with or without TFE was also found to be attractive.

(BOC)2O excess - imidazole (Im) - trifluoroethanol (TFE) - DMAP - polyDMAP

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