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Synthesis 2001; 2001(3): 0373-0375
DOI: 10.1055/s-2001-11447
short paper
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Use of PyBOP as a Convenient Activator for the Synthesis of Nitriles from Primary Amides †

D. Subhas Bose* , A. Venkat Narsaiah
  • *Organic Chemistry Division III, Fine Chemicals Laboratory, Indian Institute of Chemical Technology, Hyderabad 500 007, India; Fax + 91(40)7 17 33 87; E-mail: dsb@iict.ap.nic.in
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Publication Date:
31 December 2001 (online)

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Various types of primary carboxamides were reacted with benzotriazol-1-yloxytris(pyrrolidino)phosphonium hexafluorophosphate (PyBOP) and N-ethyldiisopropylamine to obtain the corresponding nitriles in high yields.

nitriles - amides - N-ethyldiisopropylamine - PyBOP - transformation - dehydration

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