Download PDF
Synlett 2001; 2001(2): 0218-0221
DOI: 10.1055/s-2001-10767
letter
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

Microwave-assisted Regioselective Synthesis of 2,4-Disubstituted Imidazoles: Nortopsentin D Synthesized by Minimal Effort

Pilar M. Fresneda* , Pedro Molina, Miguel A. Sanz
  • *Departamento de Química Orgánica, Facultad de Química. Universidad de Murcia, Campus de Espinardo, 30071, Murcia, Spain; Fax +34 968 364149; E-mail: pmolina§um.es; fresneda§fcu.um.es
Further Information

Publication History

Publication Date:
31 December 2001 (online)

  PDF Download  Permissions and Reprints All articles of this category

A two step regioselective synthesis of 2,4-disubstituted imidazoles based on the reaction of α-azidoacetyl indoles with carboxylic acids in the presence of tertiary phosphines followed by cyclization of the resulting ketoamides by the action of ammonium acetate under microwave irradiation is described. The method has successfully been applied to the synthesis of the antifungal nortopsentin D [2,4-bis(3-indolyl)imidazole].

nortopsentin - 2,4-disubstituted imidazoles - microwave chemistry - tertiary phosphines

      >