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Synthesis of Enantioenriched Substituted Tetrahydrofurans and Tetrahydropyrans via Iron-Mediated Chirality Transfer and Ring Closure
31 December 2000 (online)
The synthesis of optically active, functionalized tetrahydrofurans and tetrahydropyrans via Fe(CO)4-mediated cycloetherification has been accomplished. The ring closure reaction proceeds with chirality transfer and under retention of the configuration at the allylic carbon center.
cyclic ethers - allylic substitution - iron tetracarbonyl complexes - chirality transfer - enzymatic kinetic resolution - ring closure