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Synthesis of 2-Substituted Pyrrolidine Nitroxide Radicals
31 December 2000 (online)
Grignard reaction of nitrone 1 with arylmagnesium bromides afforded different pyrrolidine nitroxide radicals 2a-f, which were converted further to spin labelled ebselen 6, saccharine 11, phenols 5, 12, 13, quinone 16 and heterocycles 20, 21, 24. Paramagnetic sulfonyl chlorides 7a, 7b, 9a and methanethiosulfonate 25d capable of amino and thiol labelling, respectively, were also prepared.
Grignard reaction - free radicals - heterocycles - phenols - quinones - selenium - oxidations - reductions