Synthesis 2000; 2000(14): 2001-2003
DOI: 10.1055/s-2000-8718
short paper
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

A Practical and Highly Efficient Synthesis of α-(Trimethylsilyl)-difluoroacetates

Hideki Amii* , Takeshi Kobayashi, Kenji Uneyama
  • *Department of Applied Chemistry, Faculty of Engineering, Okayama University, Tsushimanaka 3-1-1, Okayama 700-8530, Japan; Fax +81(86)2 51 80 75; E-mail: [email protected]
Further Information

Publication History

Publication Date:
31 December 2000 (online)

An efficient method for the gram scale preparation of α-(trimethylsilyl)difluoroacetates is described. The key step involves Mg(0)-promoted selective C-F bond cleavage of readily available trifluoroacetates.