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Synthesis 2000; 2000(12): 1709-1712
DOI: 10.1055/s-2000-8208
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A Practical Synthesis of tert-Alkylamines via the Ritter Reaction with Chloroacetonitrile

Aigars Jirgensons* , Valerjans Kauss, Ivars Kalvinsh, Markus R. Gold
  • *Latvian institute of Organic Synthesis, 21 Aizkraukles Str., Riga, 1006, Latvia; Fax +3 71 (2) 7 82 81 14; E-mail: aigars@osi.lv
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Publication Date:
31 December 2000 (online)

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Ritter reaction of tertiary alcohols with chloroacetonitrile and subsequent cleavage of chloroacetyl group in the resulting chloroacetamide with thiourea is an efficient procedure for synthesis of tert-alkylamines.

Ritter reaction - tertiary alcohols - amides - amines - cleavage

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