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Synlett 2000; 2000(9): 1285-1286
DOI: 10.1055/s-2000-7165
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Synthesis of Mycophenolic Acid by Palladium-Catalyzed Three Component Coupling Reaction

Isao Shimizu* , Youngmin Lee, Yasunari Fujiwara
  • *Department of Applied Chemistry, Waseda University, 3-4-1 Okubo, Shinjuku-ku, Tokyo 169-8555, Japan; Fax +81-3-32 32-52 70; E-mail: shimizui@mn.waseda.ac.jp
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Publication Date:
31 December 2000 (online)

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Reaction of aromatic iodide 3 with isoprene and dimethyl malonate in the presence of palladium(0) catalyst gave the coupling product 4, which was converted into mycophenolic acid (1) in three steps.

mycophenolic acid - phthalide - three component coupling reaction - π-allylpalladium intermediate - palladium(0)