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Synlett 2000; 2000(9): 1360-1362
DOI: 10.1055/s-2000-7151
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Asymmetric Piperidine Synthesis via 1,3-Cyclic Sulfates

Mustafa Eskici* , Timothy Gallagher
  • *School of Chemistry, University of Bristol, Bristol BS8 1TS UK
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Publication Date:
31 December 2000 (online)

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Cyclic sulfates undergo a double alkylation with stabilized C,N-dianions derived from 3a/b to provide the piperidine ring system. The 4-substituted variant 7 affords a formal but stereochemically efficient synthesis of (S)-coniine.

piperidines - cyclic sulfates - coniine