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Synthesis 2000; 2000(10): 1439-1443
DOI: 10.1055/s-2000-7098
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Reaction of Heterocyclic Ketene Aminals with α-Bromoketones: A Convenient Synthesis of Pyrrole-Fused 1,3-Diazaheterocycles

Xiao-Ping Nie* , Mei-Xiang Wang, Zhi-Tang Huang
  • *Center for Molecular Science, Institute of Chemistry, The Chinese Academy of Sciences, Beijing 100080, China; Fax + 86(10)62 56 95 64; E-mail: huangzt@public.bta.net.cn
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Publication Date:
31 December 2000 (online)

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Heterocyclic ketene aminals reacted with α-bromoketones to give the C-alkylated heterocyclic ketene aminal intermediates which underwent a rapid cyclocondensation reaction to produce pyrrole-fused 1,3-diazaheterocycles.

heterocyclic ketene aminals - α-bromoketones - pyrrole-fused 1,3-diazaheterocycles

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