Synlett 2000; 2000(8): 1172-1174
DOI: 10.1055/s-2000-6749
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Shock Sensitivity of a Vinamidinium Bis-Perchlorate Reagent and Demonstration of a Lower Energy Alternative

John A. Ragan* , Ruth E. McDermott, Brian P. Jones, David J. am Ende, Pamela J. Clifford, Stanton J. McHardy, Steven D. Heck, Spiros Liras, Barb E. Segelstein
  • *Process Research and Development; E-mail:
Further Information

Publication History

Publication Date:
31 December 2000 (online)

"Vinamidinium" bis-perchlorate salt 1 (2-dimethylaminomethylene-1,3-bis(dimethylimmonio)-propane bis-perchlorate) was found to possess remarkably high thermal energy as well as significant shock sensitivity. A reported method for preparation of 2,5-disubstituted pyrimidines with 1 was of interest, and we found that the corresponding bis-tetrafluoroborate salt 2 was equally effective in this transformation, while possessing significantly lower thermal energy.