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Synlett 2000; 2000(5): 0680-0682
DOI: 10.1055/s-2000-6622
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Poly-NAP as Ligand for the Asymmetric Hydrogenation of Ketones

Rob ter Halle* , Emmanuelle Schulz, Michel Spagnol, Marc Lemaire
  • *Laboratoire de Catalyse et Synthèse Organique, UMR 5622, UCBL, CPE, 43 Bd du 11 Novembre 1918, 69622 Villeurbanne Cedex, France; Fax 33 (0) 4 72 43 14 08; E-mail: marc.lemaire@univ-lyon1.fr
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Publication Date:
31 December 2000 (online)

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A new heterogeneous catalytic system is described incorporating the BINAP structure as coordinating agent. In the presence of chiral diamines as auxiliaries, this ligand is efficient for the ruthenium catalyzed asymmetric hydrogenation of acetophenone (e.e. 68%) and can be reused several times without loss of selectivity and activity. The best e.e. (96%) is obtained for the reduction of 1′-acetonaphthone.

asymmetric catalysis - hydrogenation - ketones - polymer

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