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Synlett 2000; 2000(4): 550-552
DOI: 10.1055/s-2000-6564
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Deoxygenation of 5,12-Epoxy-5,12-dihydro-5,12-dimethyl-1,4-benzodioxino[2,3-g]isoquinoline with Iron Compounds. Synthesis of Antitumour Agents

Consol Bozzo* , M. Dolors Pujol
  • *Laboratori de Química Farmacèutica, Facultat de Farmàcia, Universitat de Barcelona, Av. Diagonal 643, 08028 Barcelona, Spain; Fax +(93) 4 03 59 41; E-mail: mdpujol@farmacia.far.ub.es
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Publication History

Publication Date:
31 December 2000 (online)

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Fe2(CO)9 in benzene is effective in removing the oxygen from 5,12-epoxy-5,12-dihydro-5,12-dimethyl-1,4-benzodioxino[2,3-g]isoquinoline to give 5,12-dimethyl-1,4-benzodioxino[2,3-g]isoquinoline, an analogue of ellipticine, a known antitumour agent.

deoxygenation - benzodioxins - polycyclic heterocyclic compounds

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