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Synlett 2000; 2000(3): 403-405
DOI: 10.1055/s-2000-6549
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Gallium Nonafluorobutanesulfonate as an Efficient Catalyst in Friedel-Crafts Acylation

Jun-ichi Matsuo* , Kazunori Odashima, Shū Kobayashi
  • *Graduate School of Pharmaceutical Sciences, The University of Tokyo, CREST, Japan Science and Technology Corporation (JST), Hongo, Bunkyo-ku, Tokyo 113-0033, Japan
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Publication Date:
31 December 2000 (online)

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Catalytic Friedel-Crafts acylation of even inactivated benzenes has been successfully carried out using a gallium compound. In the presence of a catalytic amount of gallium nonafluorobutanesulfonate (1-5 mol%), aromatics including inactivated benzenes such as fluorobenzene, chlorobenzene, and dichlorobenzene reacted with carboxylic acid chlorides or anhydrides to afford the corresponding aromatic ketones in good to excellent yields. Contrary to traditional understandings, catalytic Friedel-Crafts acylation was successfully carried out using the group 13 compound.

Friedel-Crafts reaction - catalyst - gallium - acylation

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