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Synlett 2000; 2000(2): 266-268
DOI: 10.1055/s-2000-6507
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Synthesis of the H-I-J Tricyclic Fragment of Ciguatoxin, a Marine Polyether Toxin

Tong-Zhu Liu* , Minoru Isobe
  • *Laboratory of Organic Chemistry, School of Bioagricultural Sciences, Nagoya University, Chikusa, Nagoya 464-8601, Japan; Fax +81-52-7 89-41 11; E-mail: isobem@agr.nagoya-u.ac.jp
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Publication Date:
31 December 2000 (online)

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During the course of our synthetic studies on ciguatoxin, synthesis of H-I-J tricyclic fragment has been stereoselectively achieved starting from a d-glucal derivative. The key steps are Sonogashira coupling reaction and cobalt complex-mediated oxocane cyclization.

ciguatoxin - biscobalthexacarbonyl - oxocane cyclization - Sonogashira coupling