Synlett 2000; 2000(1): 131-133
DOI: 10.1055/s-2000-6454
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Diisopropylcarbodiimide: A Novel Reagent for the Synthesis of 1,3,4-Oxadiazoles on Solid-Phase

Bethany J. Brown* , Ian R. Clemens, James K. Neesom
  • *Enzyme Medicinal Chemistry I, Glaxo Wellcome Research and Development, Gunnels Wood Road, Stevenage, Hertfordshire, UK SG1 2NY; Fax + 44 (0)1438 76 3438; E-mail: irc1042@glaxowellcome.co.uk
Further Information

Publication History

Publication Date:
31 December 2000 (online)

Using diisopropylcarbodiimide (DIPCDI) in DMF to effect cyclodehydration, various resin bound 1,2-diacylhydrazines were converted to the corresponding 2,5-disubstituted 1,3,4-oxadiazoles in good yields and purities.