Download PDF
Synlett 2000; 2000(1): 125-127
DOI: 10.1055/s-2000-6439
letter
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

Traceless Linking of Indoles: General Methodology and Application to Solid Phase Supported Mannich and Stille Reactions

Johannes Kraxner* , Michael Arlt, Peter Gmeiner
  • *Department of Medicinal Chemistry, Emil Fischer Center, Friedrich-Alexander University, Schuhstraße 9, D-91052 Erlangen, Germany; Fax +49 (91 31) 8 52 25 85; E-mail: gmeiner@pharmazie.uni-erlangen.de
Further Information

Publication History

Publication Date:
31 December 2000 (online)

  PDF Download  Permissions and Reprints All articles of this category

Transacetalization reaction of the diethoxymethyl (DEM) protected indoles 2a,b,d,e with the polymer bound glycerol derivative 3 resulted in formation of the immobilized indoles 4a,b,d,e. Selective indole-functionalizations as well as quantitative and traceless cleavage could be demonstrated.

solid-phase synthesis - traceless linker - indoles - Stille reaction - diethoxymethyl protection

      >