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Synthesis 2000; 2000(5): 731-737
DOI: 10.1055/s-2000-6403
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A Convenient Dehydration Procedure for the Synthesis of Enantiomerically Pure Cyanohydrins

Fabrice Aquino* , Horst Pauling, Willy Walther, Dietmar A. Plattner, Werner Bonrath
  • *Vitamins and Fine Chemical Division, Chemical Process Technology, F. Hoffmann-La Roche Ltd., CH-4070 Basel, Switzerland; Fax + 41(61)6 88 55 11; E-mail: Werner.Bonrath@Roche.com
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Publikationsdatum:
31. Dezember 2000 (online)

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Starting from protected α-hydroxy amides, cyanohydrins (α-hydroxy nitriles) are obtained through dehydration by cyanuric chloride/DMF in excellent yield. The advantages of the procedure are the extremely mild reaction conditions that prevent racemization.

dehydration - cyanuric chloride/DMF adduct - cyanohydrins