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Synthesis 2000; 2000(5): 673-676
DOI: 10.1055/s-2000-6394
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Practical Synthesis of Active Esters of 4-Alkoxycarbonylamino-3-methoxypyrrole-2-carboxylic Acid

Kesavaram Narkunan* , Marco A. Ciufolini
  • *Université Claude Bernard Lyon 1 and Ecole Supérieure de Chimie, Physique, Electronique de Lyon, 43, Boulevard du 11 Novembre 1918, 69622 Villeurbanne cedex, France; Fax + 33(4)72 43 29 63; E-mail: ciufi@cpe.fr
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Publication Date:
31 December 2000 (online)

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An efficient large scale synthesis of the HOAt active ester of 4-tert-butoxycarbonylamino-3-methoxypyrrole-2-carboxylic acid is reported.

distamycin - DNA - pyrroles - Curtius rearrangement - transesterifications - heterocycles

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