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Synthesis 2000; 2000(5): 651-654
DOI: 10.1055/s-2000-6384
short paper
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Studies on Pyrimidine-Annulated Heterocycles: A Short Synthesis of Novel 6,9-Disubstituted Cyclohepta[b]pyrimido[5,4-d]pyrrole-8(6H),10(9H)-diones

Makoto Nitta* , Yohei Tajima
  • *Department of Chemistry, Materials Research Laboratory of Bioscience and Photonics, Waseda University, Tokyo 169-8555, Japan; Fax + 81(3)32 08 27 35; E-mail: nitta@mn.waseda.ac.jp
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Publication Date:
31 December 2000 (online)

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A number of 6,9-disubstituted cyclohepta[b]pyrimido[5,4-d]pyrrole-8(6H),10(9H)-dione derivatives have been synthesized in good to moderate yields by the reaction of 6-amino-3-methyluracil derivatives with 2-chlorotropone in an enamine-alkylation process, subsequent condensation of the amino group with the carbonyl function, dehydrochlorination, and dehydration.

cyclohepta[b]pyrimido[5,4-d]pyrrole - 1-azaazulene - 2-chlorotropone - 6-amino-3-methyluracil - enamine-alkylation

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