Download PDF
Synthesis 2000; 2000(3): 411-416
DOI: 10.1055/s-2000-6351
paper
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

An Expedient Synthesis of 2-(ω-Carboxyalkyl)polyhydroxyisoflavones

Nawaf Al-Maharik* , Ilpo Mutikainen, Kristiina Wähälä
  • *Laboratory of Organic Chemistry, Department of Chemistry, P.O. Box 55, FIN-00014 University of Helsinki, Finland; Fax + (3 58)9 19 14 03 57; E-mail: Kristiina.Wahala@helsinki.fi
Further Information

Publication History

Publication Date:
31 December 2000 (online)

  PDF Download  Permissions and Reprints All articles of this category

Derivatives of the isoflavones daidzein and genistein, carrying a carboxyalkyl attachment at C-2 were prepared by cyclization of unprotected 2,4,4′-trihydroxy- or 2,4,4′,6-tetrahydroxydeoxybenzoin in the presence of a number of 1,ω-alkanedicarboxylic acid monoester monochlorides, K2CO3 and a phase-transfer catalyst in dry acetone. Hydrolysis under basic conditions of the resulting 2-(ω-alkoxycarbonylalkyl)isoflavones gives the title compounds, useful for developing RIA techniques for the analysis of the parent isoflavones.

genistein - daidzein - isoflavones - immunoassay

      >