Download PDF
Synthesis 2000; 2000(8): 1075-1077
DOI: 10.1055/s-2000-6316
short paper
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

A New Synthesis of Racemic Rosaprostol

Marian Mikołajczyk* , Maciej Mikina, Aleksandra Jankowiak, Malose J. Mphahlele
  • *Centre of Molecular and Macromolecular Studies, Polish Academy of Sciences, 90-363 Łódź, Sienkiewicza 112, Poland; Fax 0 (48 42) 6 84 71 26; E-mail: marmikol@bilbo.cbmm.lodz.pl
Further Information

Publication History

Publication Date:
31 December 2000 (online)

  PDF Download  Permissions and Reprints All articles of this category

Rosaprostol, an antiulcer drug, was prepared in five steps and in 36% overall yield starting from 3-(dimethoxyphosphorylmethyl)cyclopent-2-enone (6). The regioselective alkylation of 6 at C(2) with methyl 7-iodoheptanoate and subsequent Horner-Wittig reaction with pentanal constitute the key steps of this total synthesis.

rosaprostol - antiulcer drug - phosphonates - Horner-Wittig reaction - total synthesis

      >