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Synthesis 2000; 2000(7): 925-928
DOI: 10.1055/s-2000-6295
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The Ru3(CO)12-Catalyzed Intermolecular [2 + 2 + 1] Cyclocoupling of Imines, Alkenes or Alkynes, and Carbon Monoxide: A New Synthesis of Functionalized γ-Lactams

Naoto Chatani* , Mamoru Tobisu, Taku Asaumi, Shinji Murai
  • *Department of Applied Chemistry, Faculty of Engineering, Osaka University, Suita, Osaka 565-0871, Japan; Fax +81(6)68797396; E-mail: murai@chem.eng.osaka-u.ac.jp
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Publication Date:
31 December 2000 (online)

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The reaction of imines which contain N-heterocycles or an ester group with alkenes or alkynes and carbon monoxide in the presence of a catalytic amount of a ruthenium carbonyl results in [2 + 2 + 1] cyclocoupling to give γ-butyrolactams in good yields.

ruthenium carbonyl - [2 + 2 + 1] cyclocoupling - cycloaddition - imines - carbon monoxide