Application of the Siegrist Condensation to the Synthesis of Conjugated Enantiopure Bis(styryl)ferrocenes
31 December 1999 (online)
Enantiopure polyunsaturated bis(ferrocenyl)aldehydes 7a-c were prepared from the chiral ferrocenylimine 2b. The key reaction is a Siegrist condensation between 2b and bis-methylarenes 4a-c. Sequential introduction of two different styryl groups also gave the tris-unsaturated ferrocenecarboxaldehyde 9.
chiral ferrocenes - stilbenes - stereoselective synthesis - imines - planar chirality