Download PDF
Synthesis 1999; 1999(3): 401-403
DOI: 10.1055/s-1999-3421
short paper
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

Synthesis of Prelactone B

U. Hanefeld* , A. M. Hooper, J. Staunton
  • *Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK; E-mail: js24@cus.cam.ac.uk
Further Information

Publication History

Publication Date:
31 December 1999 (online)

  PDF Download  Permissions and Reprints All articles of this category

Prelactone B (1a) and its isomer 1b are possible products of a truncated avermectin polyketide synthase. In order to make them available as reference compounds they were synthesized in a six-step synthesis with 56% overall yield.

prelactone B - Streptomyces griseus - avermectin - polyketide synthase - aldol reaction