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Synthesis 1999; 1999(3): 401-403
DOI: 10.1055/s-1999-3421
short paper
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Synthesis of Prelactone B

U. Hanefeld* , A. M. Hooper, J. Staunton
  • *Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK; E-mail: js24@cus.cam.ac.uk
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Publikationsdatum:
31. Dezember 1999 (online)

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Prelactone B (1a) and its isomer 1b are possible products of a truncated avermectin polyketide synthase. In order to make them available as reference compounds they were synthesized in a six-step synthesis with 56% overall yield.

prelactone B - Streptomyces griseus - avermectin - polyketide synthase - aldol reaction