Preparation of New Phosphine Oxide Synthons: Synthesis of an Analogue of Muscarinic Antagonists

Roger G. Hall; Peter Riebli

doi:10.1055/s-1999-2899

Synlett 1999; 1999(10): 1633-1635
DOI: 10.1055/s-1999-2899

letter

© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

Preparation of New Phosphine Oxide Synthons: Synthesis of an Analogue of Muscarinic Antagonists

Roger G. Hall^* , Peter Riebli

^*Novartis Crop Protection AG, Basel, Switzerland; E-mail: roger_graham.hall@cp.novartis.com

Abstract

als PDF herunterladen Alle Artikel dieser Rubrik

Protected primary phosphine oxides may be obtained by reaction of ethyl (diethoxyalkyl)phosphinates with organometallic reagents. These products, stable to chromatography or distillation, may be further elaborated into new, functional unsymmetrical secondary and tertiary phosphine oxides. A close analogue of muscarinic antagonists has been prepared using this methodology.

functional phosphine oxides - synthons - muscarinic antagonists

PDF (41 kb)