Synlett 1999; 1999(10): 1660-1662
DOI: 10.1055/s-1999-2887
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Synthesis of Novel Unsaturated Bicyclic Lactams by Ring-Closing Metathesis

Catharine E. Grossmith* , Francesco Senia, Jürgen Wagner
  • *Novartis Pharma AG, CH-4002 Basel, Switzerland; Fax +41.61.324.45.13; E-mail: juergen.wagner@pharma.novartis.com
Further Information

Publication History

Publication Date:
31 December 1999 (online)

An efficient and versatile synthetic method for the preparation of novel unsaturated fused bicyclic lactams is described. The crucial step of the stereoselective approach is the ring-closing metathesis reaction. The 6,5-, 7,5- and 8,5-fused 1-aza-2-oxobicycloalkenes can be obtained in five steps and good overall yield.

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