Download PDF
Synlett 1999; 1999(9): 1423-1425
DOI: 10.1055/s-1999-2859
letter
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

Unexpected formation of O-methoxycarbonyl cyanohydrin showing potential as a protective group of ketones

Donald Poirier* , David Berthiaume, Roch P. Boivin
  • *Medicinal Chemistry Division, Laboratory of Molecular Endocrinology, Laval University Medical Research Center, 2705 Laurier Boulevard, Quebec, G1V 4G2, Canada; Fax 4 18-6 54-27 61; E-mail: donald.poirier@crchul.ulaval.ca
Further Information

Publication History

Publication Date:
31 December 1999 (online)

  PDF Download  Permissions and Reprints All articles of this category

A one-step procedure using methyl cyanoformate and a secondary alkylamine was reported to efficiently transform ketones into O-methoxycarbonyl cyanohydrins. This functional group shows interesting potential in protecting group chemistry.

protective group - ketone - cyanohydrin - carbonate

      >