The Intra- and Intermolecular Pauson-Khand Reaction Promoted by Alkyl Methyl Sulfides

Takumichi Sugihara; Mamiko Yamada; Masahiko Yamaguchi; Mugio Nishizawa

doi:10.1055/s-1999-2745

Synlett 1999; 1999(6): 771-773
DOI: 10.1055/s-1999-2745

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The Intra- and Intermolecular Pauson-Khand Reaction Promoted by Alkyl Methyl Sulfides

Takumichi Sugihara^* , Mamiko Yamada, Masahiko Yamaguchi, Mugio Nishizawa

^*Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro-cho, Tokushima 770-8514, Japan; E-mail: taku@ph-bunri-u.ac.jp

Abstract

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The Pauson-Khand reaction was promoted by the addition of alkyl methyl sulfides. Among the sulfides, the ones having primary and secondary alkyl groups were more effective than those with tertiary alkyl groups. The intermolecular cyclization with simple alkenes makes the use of n-butyl methyl sulfide as the best method to carry out the stoichiometric Pauson-Khand reaction.

cobalt - cyclization - carbonyl complexes - alkyne - sulfide

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