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Synlett 1999; 1999(6): 816-818
DOI: 10.1055/s-1999-2729
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Oxovanadium(IV) Complex-mediated Catalysis in Mukaiyama-type Aldol Additions

Chien-Tien Chen* , Sang-Wen Hon, Shiue-Shien Weng
  • *Department of Chemistry, National Taiwan Normal University, Taipei, Taiwan 117, Republic of China; Fax +11-8 86-2-29 32 42 49; E-mail: chefv043@scc.ntnu.edu.tw
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Publication Date:
31 December 1999 (online)

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Condensation of vanadyl sulfate with 2,2′-biphenol in the presence of N-containing ligands provides oxovanadium(IV) complexes which serve as efficient catalysts in Mukaiyama aldol reactions to afford aldol products in 52-100% yields with diastereoselectivities of up to 90/10 (anti/syn).

Lewis acids - 2,2′-biphenol - N-methylimidazole - diastereoselective - β-hydroxyesters

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