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Synlett 1999; 1999(6): 759-761
DOI: 10.1055/s-1999-2720
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Synthesis and Lipase-Catalyzed Enantiotope Selective Acetylation of 2-Benzoyloxy-1,3-propanediol

Viktória Bódai* , Lajos Novák, László Poppe
  • *Institute for Organic Chemistry, Technical University of Budapest, H-1111 Budapest, Gellért tér 4., Hungary
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Publication Date:
31 December 1999 (online)

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Preparation and porcine pancreatic lipase (PPL)-catalyzed enantiotope selective acetylation of the prochiral 2-benzoyloxy-1,3-propanediol (1a) is described. The reaction with PPL and vinyl acetate gave monoacetate (2a) of 96% e.e.

2-O-benzoylglycerol - enantiotope selective - acetylation - lipase