Download PDF
Synlett 1999; 1999(5): 533-536
DOI: 10.1055/s-1999-2671
letter
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

A Macrolactamisation-Oxazoline Ring Forming Approach towards the tris-Oxazole Macrolide Core in the Ulapualides

James Kempson* , Gerald Pattenden
  • *School of Chemistry, University of Nottingham, Nottingham NG7 2RD, England; Fax +44(1 15)9 51 35 35
Further Information

Publication History

Publication Date:
31 December 1999 (online)

  PDF Download  Permissions and Reprints All articles of this category

A new design for the synthesis of the 25-membered tris-oxazole macrolide core, 3, in the "ulapualide family" of marine natural products e.g. 1 isolated from nudibranchs and sponges, based on a macrolactamisation strategy, leading to 4, followed by oxazoline and oxazole ring formation using the substituted monooxazoles 5 and 6 as key precursor, is described.

marine natural products - macrolactamisation - ring-formation - oxazolines

      >