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Synlett 1999; 1999(5): 638-640
DOI: 10.1055/s-1999-2668
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Substituted Macrolactones via Oligomerisation of α-Bromomethylacrylic Acid Derivatives

Matthias F. Schneider* , Siegfried Blechert, Andreas Matuszak, Joachim Pickardt
  • *Institut für Organische Chemie, Technische Universität Berlin, Straße des 17. Juni 135, D-10623 Berlin, Germany; Fax +49(30)31 42 36 19; E-mail: sibl@wap0105.chem.tu-berlin.de
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Publication Date:
31 December 1999 (online)

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In this report we describe a new and efficient approach toward substituted oligomeric macrolactones by treatment of α-bromomethylacrylic acid derivatives with DBU. Tri- and tetrolides were obtained selectively in acceptable yields for this type of consecutive reaction sequence.

α-bromomethylacrylic acid derivatives - 2,4-dimethylen-δ-valero-lactone - oligolactones - substituted macrolactones

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